ADR Ontology |
ADR Term |
Capillary leak syndrome |
ADR ID |
BADD_A00753 |
ADR Hierarchy |
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Description |
A disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. [CTCAE] A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE. [MeSH] |
MedDRA Code |
10007196 |
MeSH ID |
D019559
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Synonym |
Capillary leak syndrome | Acute vascular leak syndrome | Capillary Leak Syndrome | Capillary Leak Syndromes | Clarkson Disease | Systemic Capillary Leak Syndrome | Clinical Capillary Leak Syndrome |
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ADR Related Proteins |
Protein Name |
UniProt AC |
TTD Target ID |
Angiopoietin-related protein 4 | Q9BY76 | T98635 |
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Drugs Leading to the ADR |
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